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KMID : 0356919930260030598
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Korean Journal of Anesthesiology
1993 Volume.26 No. 3 p.598 ~ p.601
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Case Report of Sevoflurane Anesthesia in Healthy Patient
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Abstract
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We report a case of sevoflurane anesthesia. Sevoflurane is a halogenated methyl isopropyl ether which was synthesized first in the early 1970s. In 1975, Wallin RF and his colleagues first reported on physicochemical, pharmacologic, and
toxicologic
properties of sevoflurane. They noted that frequent exposures of dogs and rats to sevoflurane over a period of 2 weeks did not result in any significant toxicologic changes and did not sensitize the heart to epinephrine. It has a blood: gas
partition
coefficient of 0.60 which is lower than that of other currently used inhalational volatile agents. Its MAC value has been reported to vary between 1.71 and 2.5%. From reports of studies in adult volunteers and Japanese children it is clear that
induction of anesthesia by sevoflurane is rapid and smooth as predicted by a blood: gas partition coefficient of about 0.6 and acceptable odour which allows the use of overpressure concentrations of up to 10%. Other animal investigations indicate
that
sevoflurane provides no organotoxicity. In this study we observed induction-emergence time, hemodynamic changes and postoperative hepatorenal effects in healthy surgical patients receiving sevoflurane anesthesia.
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